No. Performing sets of 50 reps may get you huffing and puffing, but such training doesn’t work as well for fat loss as the standard hypertrophy (i.e., muscle building) bracket of 8-12 reps.
When concentrating on fat loss, you need to maximise muscle-mass retention to keep your metabolism at its maximum. To ensure this, keep your reps within the hypertrophy zone, which means keeping the total exercise time for your tempo prescription between 40 and 70 seconds.
Also, make certain to use “the most bang for your buck” exercises (i.e., compound exercises, such as squats deadlifts overhead presses and chin-ups, that work the largest muscle groups) to ensure maximal caloric output.